Ipamorelin

Ipamorelin is a pentapeptide GH secretagogue that stimulates growth hormone release by acting on the GH secretagogue receptor (GHS-R). What sets Ipamorelin apart from earlier secretagogues like GHRP-6 and GHRP-2 is its selectivity: studies have shown it produces robust GH release with significantly less impact on cortisol and prolactin levels.

This selectivity makes Ipamorelin a cleaner tool for GH research. Studies that need to isolate GH effects without the confounding influence of cortisol elevation have increasingly moved toward Ipamorelin. It is most commonly studied in combination with CJC-1295 (without DAC).

Research Applications

• GH axis research — Selective GHS-R agonism with minimal off-target hormonal effects
• Combination studies — Synergistic GH release when paired with CJC-1295 No DAC
• Body composition models — GH-mediated lipolysis and protein synthesis in animal studies
• Sleep & GH pulse research — Studies on GH release during rest cycles

Specifications

• Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH₂
• Molecular Weight: 711.9 g/mol
• CAS Number: 170851-70-4
• Form: White lyophilized powder
• Purity: ≥99% (HPLC verified)
• Storage: −20°C, protected from light