A neuropeptide acting on the hypothalamic-pituitary-gonadal axis, studied for its role in reproductive hormone regulation, GnRH pulse signaling, and neuroendocrine research.
Kisspeptin-10 (Kp-10) is the C-terminal decapeptide of kisspeptin-54, encoded by the KISS1 gene and acting as the endogenous ligand for KISS1R (formerly GPR54). Kisspeptin signaling at the hypothalamic level is essential for GnRH pulse generation — positioning kisspeptin as the central upstream regulator of the HPG axis.
Research has established that kisspeptin neurons in the arcuate nucleus act as the GnRH pulse generator, integrating metabolic signals, steroid hormone feedback, and circadian inputs to regulate reproductive function. KISS1R agonism with Kisspeptin-10 reliably stimulates GnRH release, driving LH and FSH secretion — making it an important tool for studying gonadotropin dynamics, ovulation timing, and HPG axis physiology.
Active research areas include the neuroendocrine basis of puberty onset, fertility regulation, effects of energy availability on reproductive function, and kisspeptin's role in sexual behavior and limbic function. Evidence suggests KISS1R signaling influences mood and approach-avoidance behavior beyond its endocrine role.
| Form | Lyophilized Powder |
|---|---|
| Dosage Per Vial | 5mg |
| Molecular Weight | 1302.54 g/mol |
| CAS Number | 374683-17-7 |
| Sequence / Structure | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| Purity | ≥99% (HPLC verified) |
| Storage | Store at −20°C. Reconstitute with sterile water. Use within 48 hours of reconstitution. |
| Research Use | In vitro / laboratory research only |
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