SLU-PP-332

SLU-PP-332 is a small molecule pan-agonist of the estrogen-related receptors alpha, beta, and gamma (ERRα/β/γ) — orphan nuclear receptors that function as master regulators of mitochondrial biogenesis, fatty acid oxidation, and oxidative phosphorylation. ERR receptors are regulated by coactivators including PGC-1α, the principal transcriptional mediator of exercise-induced mitochondrial adaptation.

Research published in 2024 demonstrated that SLU-PP-332 administration in mice significantly increased skeletal muscle oxidative capacity, mitochondrial content, and exercise performance — effects that closely parallel aerobic exercise training without physical activity. Treated animals showed increased running distance and fatigue resistance, earning the compound classification as a potential exercise mimetic alongside AICAR and GW501516, but via a distinct ERR-mediated mechanism.

Research applications include exercise physiology, mitochondrial biogenesis signaling, skeletal muscle adaptation, and investigation of the molecular basis of exercise benefits. As a powder, dissolve in DMSO for cell culture applications. No refrigeration required for storage — store in a cool, dry location.