TB-500

TB-500 is a synthetic peptide corresponding to the active region of Thymosin Beta-4 (Tβ4), a naturally occurring protein involved in cell proliferation, migration, and tissue repair. The specific sequence is the actin-binding domain of Tβ4 — the portion researchers have identified as carrying most of the protein's functional activity.

Research interest in TB-500 centers on its role in promoting cell migration to injury sites, facilitating angiogenesis, and reducing localized inflammation. Animal studies across cardiac, musculoskeletal, and wound healing models have shown consistent involvement of Tβ4 in tissue repair processes.

Research Applications

• Cardiac repair — Reduced cell death and improved recovery in myocardial infarction animal models
• Wound healing — Accelerated wound closure via increased cell migration and angiogenesis
• Tendon & musculoskeletal — Soft tissue injury research; notable equine studies
• CNS repair — Emerging research on stroke recovery and spinal cord injury models

Specifications

• Sequence: Ac-Ser-Asp-Lys-Pro (active fragment, 17 amino acids)
• Molecular Weight: ~2,888 g/mol
• CAS Number: 77591-33-4
• Form: White lyophilized powder
• Purity: ≥99% (HPLC verified)
• Storage: −20°C, protected from light; reconstitute with bacteriostatic water